I have been promulgating a unifying membrane model called the proteolipid code:
Kervin, T.A., Overduin, M. Membranes are functionalized by a proteolipid code. BMC Biol 22, 46 (2024). https://doi.org/10.1186/s12915-024-01849-6
Overduin, M. et al. Deciphering the language of mingling lipids and proteins. Curr. Opin. Struct. Biol. 92, 103061 (2025). https://doi.org/10.1016/j.sbi.2025.103061
Kervin, T.A. No phases? No phase separation. Zenodo (2025). https://doi.org/10.5281/zenodo.17201252
website: https://proteolipid.org
What are your thoughts? While it has long been suggested there there is a “membrane code” or “lipid code”, our model is falsifiable and rejects original and modified lipid raft theories. I have plans to make it more specific and formalize it with category theory. A database of membrane zones is a future direction.
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